Titre :
  • Oxidation sensitivity may be a useful tool for the detection of the hematotoxic potential of newly developed molecules: application to antipsychotic drugs
Auteur : Kauffmann, Jean-Michel ; Liégeois, Jean-François ; Bruhwyler, Jacques ; Petit, Christine ; Damas, Jacques ; Delarge, Jacques ; Geczy, Joseph ; Lamy, Maurice ; Meltzer, Herbert ; Mouithys-Mickalad, Ange
Informations sur la publication : Archives of Biochemistry and Biophysics, 370, 1, (page 126-137)
Statut de publication : Publié, 1999
Sujet CREF : Chimie analytique
Mots-clés : Agranulocytosis
Antipsychotic
Clozapine
Oxidation
Predictiv e model
Pyridobenzazepine
Mots-clés MeSH : Agranulocytosis -- chemically induced
Anemia, Aplastic -- chemically induced
Antipsychotic Agents -- chemistry
Antipsychotic Agents -- pharmacokinetics
Antipsychotic Agents -- toxicity
Benzazepines -- chemistry
Benzazepines -- pharmacokinetics
Benzazepines -- toxicity
Electron Spin Resonance Spectroscopy
Hematologic Diseases -- chemically induced
Horseradish Peroxidase -- metabolism
Humans
Oxidation-Reduction
Pyrimidinones -- chemistry
Pyrimidinones -- pharmacokinetics
Pyrimidinones -- toxicity
Structure-Activity Relationship
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0003-9861 
info:doi/10.1006/abbi.1999.1380
info:pii/S0003-9861(99)91380-2
info:pmid/10496986
jmk-0109