Titre:
  • Oxidation sensitivity may be a useful tool for the detection of the hematotoxic potential of newly developed molecules: application to antipsychotic drugs
Auteur:Kauffmann, Jean-Michel; Liégeois, Jean-François; Bruhwyler, Jacques; Petit, Christine; Damas, Jacques; Delarge, Jacques; Geczy, Joseph; Lamy, Maurice; Meltzer, Herbert; Mouithys-Mickalad, Ange
Informations sur la publication:Archives of Biochemistry and Biophysics, 370, 1, page (126-137)
Statut de publication:Publié, 1999
Sujet CREF:Chimie analytique
Mots-clés:Agranulocytosis
Antipsychotic
Clozapine
Oxidation
Predictiv e model
Pyridobenzazepine
MeSH keywords:Agranulocytosis -- chemically induced
Anemia, Aplastic -- chemically induced
Antipsychotic Agents -- chemistry
Antipsychotic Agents -- pharmacokinetics
Antipsychotic Agents -- toxicity
Benzazepines -- chemistry
Benzazepines -- pharmacokinetics
Benzazepines -- toxicity
Electron Spin Resonance Spectroscopy
Hematologic Diseases -- chemically induced
Horseradish Peroxidase -- metabolism
Humans
Oxidation-Reduction
Pyrimidinones -- chemistry
Pyrimidinones -- pharmacokinetics
Pyrimidinones -- toxicity
Structure-Activity Relationship
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0003-9861
info:doi/10.1006/abbi.1999.1380
info:pii/S0003-9861(99)91380-2
info:scp/0342280928
info:pmid/10496986
jmk-0109