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The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein.

par Wouters, An;Pauwels, Bea;Burrows, Natalie;Baay, Marc;Deschoolmeester, Vanessa;Vu, Trung Nghia;Laukens, Kris;Meijnders, Paul;Van Gestel, Dirk ;Williams, Kaye J;Van den Weyngaert, Danielle;Vermorken, Jan B;Pauwels, Patrick;Peeters, Marc;Lardon, Filip
Référence BMC cancer, 14, page (594)
Publication Publié, 2014-08

Article révisé par les pairs

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Résumé :

Regions within solid tumours often experience oxygen deprivation, which is associated with resistance to chemotherapy and irradiation. The aim of this study was to evaluate the radiosensitising effect of gemcitabine and its main metabolite dFdU under normoxia versus hypoxia and to determine whether hypoxia-inducible factor 1 (HIF-1) is involved in the radiosensitising mechanism.