Titre:
  • Cabozantinib targets bone microenvironment modulating human osteoclast and osteoblast functions.
Auteur:Fioramonti, Marco; Santini, Daniele; Iuliani, Michele; Ribelli, Giulia; Manca, Paolo; Papapietro, Nicola; Spiezia, Filippo; Vincenzi, Bruno; Denaro, Vincenzo; Russo, Antonio; Tonini, Giuseppe; Pantano, Francesco
Informations sur la publication:Oncotarget, 8, 12, page (20113-20121)
Statut de publication:Publié, 2017-03
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:bone microenvironment
cabozantinib
human primary cells
osteoprotegerin (OPG)
receptor activator of nuclear factor-kb ligand (RANKL)
MeSH keywords:Anilides -- pharmacology
Apoptosis
Blotting, Western
Bone Resorption -- drug therapy -- metabolism -- pathology
Cell Differentiation -- drug effects
Cell Proliferation
Cells, Cultured
Humans
Immunoenzyme Techniques
Osteoblasts -- cytology -- drug effects -- physiology
Osteoclasts -- cytology -- drug effects -- physiology
Osteogenesis -- drug effects -- physiology
Osteoprotegerin -- genetics -- metabolism
Proto-Oncogene Proteins c-met -- genetics -- metabolism
Pyridines -- pharmacology
RANK Ligand -- genetics -- metabolism
RNA, Messenger -- genetics
Real-Time Polymerase Chain Reaction
Receptor Activator of Nuclear Factor-kappa B -- genetics -- metabolism
Reverse Transcriptase Polymerase Chain Reaction
Langue:Anglais
Identificateurs:urn:issn:1949-2553
info:doi/10.18632/oncotarget.15390
info:pii/15390
info:pmid/28223547
PMC5386748