Titre:
  • Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions.
Auteur:Picco, Gabriele; Petti, Consalvo; Centonze, Alessia; Torchiaro, Erica; Crisafulli, Giovanni; Novara, Luca; Acquaviva, Andrea; Bardelli, Alberto; Medico, Enzo
Informations sur la publication:EMBO molecular medicine, 9, 3, page (293-303)
Statut de publication:Publié, 2017-03
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:R‐spondin
WNT pathway
colorectal cancer
gene fusion
targeted therapy
MeSH keywords:Axin Protein -- deficiency
Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms -- pathology
Drug Resistance
Enzyme Inhibitors -- pharmacology
Gene Fusion
Humans
Pyrazines -- pharmacology
Pyridines -- pharmacology
Thrombospondins -- genetics
Wnt Proteins -- metabolism
Wnt Signaling Pathway
Langue:Anglais
Identificateurs:urn:issn:1757-4676
info:doi/10.15252/emmm.201606773
info:pii/emmm.201606773
info:pmid/28100566
PMC5331210