par Buisseret, Laurence ;Pommey, Sandra;Allard, Bertrand;Garaud, Soizic ;Bergeron, M.;Cousineau, I;Ameye, L.;Bareche, Yacine ;Paesmans, Marianne ;Crown, John;Di Leo, Angelo ;Loi, Sherene ;Piccart-Gebhart, Martine ;Willard-Gallo, Karen ;Sotiriou, Christos ;Stagg, John
Référence Annals of oncology
Publication Publié, 2017-11
Référence Annals of oncology
Publication Publié, 2017-11
Article révisé par les pairs
Résumé : | CD73 is an ecto-enzyme that promotes tumor immune escape through the production of immunosuppressive extracellular adenosine in the tumor microenvironment. Several CD73 inhibitors and adenosine receptor antagonists are being evaluated in phase I clinical trials. |