Titre :
  • Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.
Auteur : Gurzov, Esteban Nicolas ; Tran, Melanie M ; Fernandez-Rojo, Manuel MA ; Merry, Troy TL ; Zhang, Xinmei X ; Xu, Yang Y ; Fukushima, Atsushi A ; Waters, Jonathan Michael J.M. ; Watt, Matthew J MJ ; Andrikopoulos, Sofianos S ; Neel, Benjamin BG ; Tiganis, Tony T
Informations sur la publication : Cell Metabolism, 20, 1, (page 85-102)
Statut de publication : Publié, 2014-07
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Animals
Cells, Cultured
Diet, High-Fat
Female
Glutathione Peroxidase -- deficiency -- genetics -- metabolism
Growth Hormone -- metabolism
Hepatocytes -- cytology -- metabolism
Insulin -- metabolism -- pharmacology
Insulin-Like Growth Factor I -- metabolism
Liver -- enzymology -- metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Obesity -- metabolism -- pathology
Oxidative Stress
Protein Tyrosine Phosphatase, Non-Receptor Type 2 -- deficiency -- genetics -- metabolism
Reactive Oxygen Species -- metabolism
STAT1 Transcription Factor -- metabolism
STAT3 Transcription Factor -- metabolism
STAT5 Transcription Factor -- genetics -- metabolism
Signal Transduction -- drug effects
Langue :
  • Anglais
Identificateurs : urn:issn:1550-4131 
info:doi/10.1016/j.cmet.2014.05.011
info:pii/S1550-4131(14)00219-8
info:pmid/24954415
info:pmcid/PMC4335267