Titre :
  • KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
Auteur : Cuttano, Roberto R ; Rudini, Noemi N ; Bravi, Luca L ; Corada, Monica M ; Giampietro, Costanza C ; Papa, Eleanna E ; Morini, Marco Francesco MF ; Maddaluno, Luigi L ; Baeyens, Nicolas ; Adams, Ralf H RH ; Jain, Mukesh MK ; Owens, Gary GK ; Schwartz, Martin A MA ; Lampugnani, Maria Grazia MG ; Dejana, Elisabetta E
Informations sur la publication : EMBO molecular medicine, 8, 1, (page 6-24)
Statut de publication : Publié, 2016-01
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : CCM
EndMT
KLF4
TGFβ‐BMP
endothelial cells
Mots-clés MeSH : Animals
Bone Morphogenetic Protein 6 -- antagonists & inhibitors -- genetics -- metabolism
Cell Proliferation
Disease Models, Animal
Disease Progression
Endothelial Cells -- cytology -- metabolism
HEK293 Cells
Hemangioma, Cavernous, Central Nervous System -- genetics -- metabolism -- pathology
Humans
Kruppel-Like Transcription Factors -- antagonists & inhibitors -- genetics -- metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Microtubule-Associated Proteins -- antagonists & inhibitors -- genetics -- metabolism
Mitogen-Activated Protein Kinase 7 -- metabolism
Mutation
Proto-Oncogene Proteins -- antagonists & inhibitors -- genetics -- metabolism
RNA Interference
Signal Transduction
Smad1 Protein -- metabolism
Transforming Growth Factor beta -- metabolism
Langue :
  • Anglais
Identificateurs : urn:issn:1757-4676 
info:doi/10.15252/emmm.201505433
info:pii/emmm.201505433
info:pmid/26612856
info:pmcid/PMC4718159