par Vanderhoeft, Patrick ;Derks, Christian ;De Francquen, Philippe ;Rozencwajg, J.
Référence Journal of thoracic and cardiovascular surgery, 69, 2, page (196-202)
Publication Publié, 1975
Article révisé par les pairs
Résumé : Fourteen anesthetized dogs remained in apnea for 1 to 4 hr on total extracorporeal breathing through a Lande Edwards membrane oxygenator (LEMO). The LEMO was directly perfused by the right heart in total pulmonary bypass, without a pump or reservoir, as an external artificial lung. A 2 sq. M. LEMO proved adequate for a dog weighing 10 kg. Pulmonary arterial pressure increased 60% of the base line value at the start of bypass because of transitory LEMO resistance, three times the normal pulmonary resistance; the pressure then returned to the initial value. Systemic arterial pressure dropped to 61% on bypass. The heart did not fail. Cardiac output, central venous pressure and the electrocardiogram remained unchanged. P(O2) at the LEMO outlet was more than 200 mm Hg. Oxygen transfer was less than 20 ml per min per square m because of hemodilution and hypothermia. Dogs survived if bypass was arrested after 1 hr; if not, they died after an average of 3 hr, 20 min on bypass.