Negative regulation of cyclic-AMP levels by carbamylcholine in dog thyroid is not mediated by cyclic-GMP

Gervy Decoster, Christine; Dumont, Jacques Emile

doi:doi/10.1016/0006-2952(85)90680-X

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Negative regulation of cyclic-AMP levels by carbamylcholine in dog thyroid is not mediated by cyclic-GMP

par Gervy Decoster, Christine

;Dumont, Jacques Emile

Référence Biochemical pharmacology, 34, 9, page (1429-1433)
Publication Publié, 1985-05

Article révisé par les pairs

Résumé :

Carbamylcholine, through calcium, enhances cyclic-GMP accumulation and depresses cyclic-AMP accumulation in TSH stimulated dog thyroid. The results presented show that compounds which can be transformed to nitric oxide increase cyclic-GMP accumulation in the dog thyroid. These compounds do not require extracellular calcium for their action. In thyroid stimulated by TSH, these compounds do not depress AMP accumulation. Cyclic-GMP is not the main intracellular signal involved in the negative regulation of cyclic-AMP levels in dog thyroid. © 1985.

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