par Charbonnier, Louis-Marie ;Vokaer, Benoît ;Lemaitre, Philippe ;Le Moine, Alain
Référence IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity, Springer Basel, page (177-185)
Publication Publié, 2013-01
Partie d'ouvrage collectif
Résumé : The recent interest for Th17 cells immediately raised questions about their possible involvement in allogeneic processes. Indeed, IL-17-producing innate immune cells and Th17 cells have now been related to allograft rejection and ischemia-reperfusion injury in clinical settings and in experimental models. Some of them clearly established a link between the presence of these cells and the development of long-term graft dysfunction. A pivotal role of a Th17-mediated pathway in transplant damage has been demonstrated independently of MHC disparities with T cells recognizing either autoantigen or minor transplantation antigen. The ambiguous relationship between regulatory T cells (Treg) and Th17 cells also complicates Treg-based therapy. Herein, we briefly discuss recent studies reporting Th17 and IL-17 involvements in allograft rejection processes.