par Carbone, Marianna;Gavagnin, Margherita;Letizia Ciavatta, M.;Mathieu, Véronique ;Ingels, Aude ;Kiss, Robert ;Pascale, Paola;Mollo, Ernesto;Ungur, Nicon;Guo, Yue-Wei
Référence Journal of natural products, 80, 5, page (1339-1346)
Publication Publié, 2017-05
Référence Journal of natural products, 80, 5, page (1339-1346)
Publication Publié, 2017-05
Article révisé par les pairs
Résumé : | A new diacylguanidine, actinofide (1), has been isolated from the marine mollusk Actinocyclus papillatus. The structure, exhibiting a guanidine moiety acylated by two terpenoid acid units, has been established by spectroscopic methods and secured by synthesis. Following this, a series of structural analogues have been synthesized using the same procedure. All of the compounds have been evaluated in vitro for the growth inhibitory activity against a variety of cancer cell lines. |