Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells
par Hanoteau, Aurélie 
;Henin, Coralie ;Svec, David;Bisilliat Donnet, Charlotte ;Denanglaire, Sébastien ;Colau, Didier J. ;Romero, Pedro;Leo, Oberdan ;Van den Eynde, Benoît J;Moser, Muriel
Référence Oncoimmunology
Publication Publié, 2017
;Henin, Coralie ;Svec, David;Bisilliat Donnet, Charlotte ;Denanglaire, Sébastien ;Colau, Didier J. ;Romero, Pedro;Leo, Oberdan ;Van den Eynde, Benoît J;Moser, Muriel Référence Oncoimmunology
Publication Publié, 2017
Article révisé par les pairs
| Résumé : | An important question is how chemotherapy may (re-)activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8+ T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed, characterized by higher KLRG-1 expression, lower PD-1 expression and increased cytotoxicity. This suggests re-engagement of T lymphocytes into the effector program. IFN-I appears involved in this remodeling. Our findings provide some insight into how cyclophosphamide regulates the amplitude and quality of tumor-specific immune responses. |
