par Nokin, Pierre ;Clinet, Martine;Swillens, Stéphane ;Delisée, Chantal ;Meysmans, Louis;Chatelain, Pierre
Référence Journal of cardiovascular pharmacology, 8, 5, page (1051-1057)
Publication Publié, 1986
Référence Journal of cardiovascular pharmacology, 8, 5, page (1051-1057)
Publication Publié, 1986
Article révisé par les pairs
Résumé : | The possible interaction between the antianginal and antiarrhythmic drug amiodarone and the slow calcium channel was investigated by competition binding experiments in guinea-pig cerebral cortex and rat heart membranes using [3H]nitrendipine as radioligand. Amiodarone displaced specifically bound [3H]nitrendipine from cerebral cortex and cardiac membranes in an apparently competitive manner. In saturation binding experiments, apparent affinity for [3H]nitrendipine progressively decreased with increasing concentrations of amiodarone, whereas maximal binding capacity (B |