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Enantioselective bioanalysis of beta‐blocking agents: Focus on atenolol, betaxolol, carvedilol, metoprolol, pindolol, propranolol and sotalol

par Egginger, Gabriele;Lindner, Wolfgang;Vandenbosch, C;Massart, Désiré Luc
Référence BMC. Biomedical chromatography, 7, 6, page (277-295)
Publication Publié, 1993

Article révisé par les pairs

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Résumé :

The recent developments in enantioselective HPLC‐separation techniques are impressive and are driven by industrial and academic interests; thus there is for instance a high demand for developing stereoselective assays for chiral drugs in biological fluids. The beta‐blocking agents, which possess an amino‐ propanol‐ or ‐ethanol side chain with at least one chiral centre, represent one of the most intensively investigated groups of more than 40 drugs introduced world wide. Seven of the most popular beta‐blockers were chosen as representatives: atenolol; betaxolol; carvedilol; metoprolol; pindolol; propranolol; and sotalol, these span the whole range of lipophilicity to hydrophilicity (polarity). Enantioselective HPLC bioassays for these β‐blockers published so far, including techniques based on chiral derivatizing agents (CDAs), chiral stationary phases (CSPs) and chiral mobile phase additives (CMPAs) have been reviewed and documented in the light of general aspects together with pharmacokinetic and pharmacodynamic considerations. Copyright © 1993 John Wiley & Sons, Ltd.