Article révisé par les pairs
| Résumé : | The combination of a thin-layer electrochemical cell with differential pulse voltammetry can be used to determine chlorpromazine in plasma and urine. The thin-layer cell (23 μl capacity) has a wax-impregnated graphite electrode. Direct determination of chlorpromazine in urine gave a linear calibration curve for the range 4.8 × 10-3-2.4 × 10-4 M with 97% recovery. No interference from glutethimide, dextropropoxyphene, meprobamate, diazepam, and methaqualone-HCl was detected. Direct measurement of chlorpromazine in plasma gave a linear calibration curve for the range 2.4 × 10-5-4.8 × 10-4 M with 89% recovery. The procedure for plasma and urine requires only 2 min per determination. Detection levels are below that required for monitoring therapeutic levels of chlorpromazine in urine. © 1981. |
