par Bettens, Bernard ;Dubois, Emile
Référence Journal of labelled compounds & radiopharmaceuticals, 8, 3, page (379-396)
Publication Publié, 1972
Article révisé par les pairs
Résumé : The experimental determination of the exchange rate, first between the tritium fixed on the OH function and the hydrogen of the nucleus, and then between the tritium specifically fixed on the cycle and the OH function has been studied. The experimental results are obtained by two different ways, the lyophilisation and the transformation in the corresponding phenolate. By means of the experimental values we have calculated the activation energy of the exchange. With these values, it is possible to show that : a) due to its stability, the molecule can be use as tracer at high temperature in gazeous phase. b) the compounds with labile hydrogene have a certain catalytic effect on the isotopic exchange. Copyright © 1972 John Wiley & Sons, Ltd.