Computational properties of mitochondria in T cell activation and fate

Uzhachenko, Roman; Shanker, Anil; Dupont, Geneviève

doi:doi/10.1098/rsob.160192

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Computational properties of mitochondria in T cell activation and fate

par Uzhachenko, Roman ;Shanker, Anil ;Dupont, Geneviève

Référence Open biology, 6, 11, 160192
Publication Publié, 2016

Article révisé par les pairs

Résumé :

In this article, we review how mitochondrial Ca2+ transport (mitochondrial Ca2+ uptake and Na+/Ca2+ exchange) is involved in T cell biology, including activation and differentiation through shaping cellular Ca2+ signals. Based on recent observations, we propose that the Ca2+ crosstalk between mitochondria, endoplasmic reticulum and cytoplasm may form a proportional-integral-derivative (PID) controller. This PID mechanism (which is well known in engineering) could be responsible for computing cellular decisions. In addition, we point out the importance of analogue and digital signal processing in T cell life and implication of mitochondrial Ca2+ transport in this process.

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