Localization of interleukin 6 mRNA in human tonsils by in situ hybridization

Bosseloir, Alain; Peters, Elisabeth; Heinen, Ernst; Cormann, Nadine; Kinet‐Denoël, CÉCile; Vanhaelst, Luc; Simar, Léon

doi:doi/10.1002/eji.1830191230

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Localization of interleukin 6 mRNA in human tonsils by in situ hybridization

par Bosseloir, Alain

;Peters, Elisabeth

;Heinen, Ernst ;Cormann, Nadine ;Kinet‐Denoël, CÉCile ;Vanhaelst, Luc

;Simar, Léon
Référence European Journal of Immunology, 19, 12, page (2379-2381)
Publication Publié, 1989

Article révisé par les pairs

Résumé :

We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S‐labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles. Copyright © 1989 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

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