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HIV latency: should we shock or lock?

par Darcis, Gilles ;Van Driessche, Benoît ;Van Lint, Carine
Référence Trends in immunology
Publication Publié, 2017

Article révisé par les pairs

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Résumé :

Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable viral replication because HIV-1 persists in viral latent reservoirs. Improved understanding of the molecular mechanisms involved in HIV-1 latency has paved the way for innovative strategies that attempt to purge latent virus. In this article we discuss the results of the broadly explored ‘shock and kill’ strategy, and also highlight the major hurdles facing this approach. Finally, we present recent innovative works suggesting that locking out latent proviruses could be a potential alternative therapeutic strategy.