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An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers.

par Bottai, Giulia;Raschioni, Carlotta;Losurdo, Agnese;Di Tommaso, Luca;Tinterri, Corrado;Torrisi, Rosalba;Reis-Filho, Jorge Sergio;Roncalli, Massimo;Sotiriou, Christos ;Santoro, Armando;Mantovani, Alberto;Loi, Sherene ;Santarpia, Libero
Référence Breast cancer research, 18, 1, page (121)
Publication Publié, 2016-12

Article révisé par les pairs

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Résumé :

Stromal tumor-infiltrating lymphocytes (TILs) are a robust prognostic factor in triple-negative breast cancer (TNBC). However, the clinical significance of TILs may be influenced by the complex landscape of the tumor immune microenvironment. In this study, we aimed to evaluate the composition and the functionality of lymphocytic infiltration and checkpoint receptors in TNBC.