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Role of fulvestrant in the treatment of postmenopausal metastatic breast cancer patients

par Poggio, Francesca;Lambertini, Matteo ;Blondeaux, Eva;Vaglica, Marina;Levaggi, Alessia;Pronzato, Paolo;Del Mastro, Lucia
Référence Expert Review of Clinical Pharmacology, 9, 9, page (1153-1161)
Publication Publié, 2016-09

Article révisé par les pairs

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Résumé :

Introduction: Endocrine therapy is considered the cornerstone treatment for postmenopausal women with hormone-receptor positive metastatic breast cancer. Fulvestrant is a selective estrogen receptor down-regulator (SERD) with demonstrated activity and efficacy in the treatment of these patients. Areas covered: The present manuscript aims to review the mechanism of action of fulvestrant, the clinical efficacy data with the use of different dosages and schedules, and finally its role in association with other medications. Expert commentary: Fulvestrant is an active compound with an excellent safety profile for the treatment of women with hormone receptor-positive metastatic breast cancer, The combination of fulvestrant with targeted agents showed increased efficacy and is expected to become a new standard treatment. Results of two clinical trials (i.e. the FALCON and FEVEX trials) are awaited to better clarify the place of fulvestrant in the armamentarium of the available therapies for the treatment of hormone receptor-positive metastatic breast cancer.