par Soubhye, Jalal 
;Meyer, Franck ;Furtmüller, Paul G;Obinger, Christian;Dufrasne, François ;Van Antwerpen, Pierre
Référence Future Medicinal Chemistry, 8, 11, page (1163-1177)
Publication Publié, 2016-07
;Meyer, Franck ;Furtmüller, Paul G;Obinger, Christian;Dufrasne, François ;Van Antwerpen, Pierre Référence Future Medicinal Chemistry, 8, 11, page (1163-1177)
Publication Publié, 2016-07
Article révisé par les pairs
| Résumé : | Despite its important role in the immune system, myeloperoxidase (MPO) is implicated in a wide range of inflammatory syndromes due to its oxidative product HOCl. The oxidative damages caused by MPO make it a new target for developing promising anti-inflammatory agents. In this paper, we tried to understand the mechanism of MPO inhibition in order to facilitate the drug design, to develop more accurate virtual tests and to understand the structure-activity relationship. |
