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Tumor Inhibiting Properties of Stereoisomeric [1,2‐Bis(3‐hydroxyphenyl)ethylenediamine]dichloroplatinum(II)‐Complexes, Part I: Synthesis

par Jennerwein, Margaretha;Gust, Ronald;Müller, Richard;Schönenberger, Helmut;Engel, Jürgen;Berger, Martin Reinhold;Schmähl, Dietrich;Seeber, Siegfried;Osieka, Reinhardt;Atassi, Ghanem ;Bock, Danièle Maréchal‐De
Référence Archiv der Pharmazie, 322, 1, page (25-29)
Publication Publié, 1989

Article révisé par les pairs

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Résumé :

The synthesis of the stereoisomeric 1,2‐bis(3‐hydroxyphenyl)ethylenediamines (1–4) from meso‐1,2‐bis(2‐hydroxyphenyl)ethylenediamine and 3‐methoxybenzaldehyde by a diaza‐Cope‐rearrangement and subsequent ether cleavage with BBr3 and their conversion into the [1,2‐bis(3‐hydroxyphenyl)ethylenediamine]dichloroplatinum(II)‐complexes with K2PtCl4 (1‐PtCl2–4‐PtCl2) is described. Copyright © 1989 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim