Titre:
  • Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.
Auteur:Aldib, Iyas; Gelbcke, Michel; Soubhye, Jalal; Prévost, Martine; Furtmüller, Paul G; Obinger, Christian; Elfving, Betina; Chikh Alard, Ibaa; Roos, Goedele; Delporte, Cédric; Berger, Gilles; Dufour, Damien; Zouaoui Boudjeltia, Karim; Neve, Jean; Dufrasne, François; Van Antwerpen, Pierre
Informations sur la publication:European journal of medicinal chemistry, 123, page (746-762)
Statut de publication:Publié, 2016-07
Sujet CREF:Chimie organique
Chimie pharmaceutique
Mots-clés:Bis-arylalkylamines derivatives
Docking
Myeloperoxidase selective inhibitors
Pharmacomodulation
Reversible inhibitors
SERT
MeSH keywords:Amines -- chemical synthesis -- chemistry -- metabolism -- pharmacology
Chemistry Techniques, Synthetic
Drug Design
Enzyme Inhibitors -- chemical synthesis -- chemistry -- metabolism -- pharmacology
Halogenation
Humans
Kinetics
Molecular Docking Simulation
Oxidation-Reduction
Peroxidase -- antagonists & inhibitors -- chemistry -- metabolism
Protein Conformation
Serotonin Uptake Inhibitors -- chemical synthesis -- chemistry -- metabolism -- pharmacology
Structure-Activity Relationship
Note générale:SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0223-5234
info:doi/10.1016/j.ejmech.2016.07.053
info:pii/S0223-5234(16)30616-X
info:scp/84981313418
info:pmid/27537923