Titre :
  • Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.
Auteur : Aldib, Iyas ; Gelbcke, Michel ; Soubhye, Jalal ; Prévost, Martine ; Furtmüller, Paul G ; Obinger, Christian ; Elfving, Betina ; Chikh Alard, Ibaa ; Roos, Goedele ; Delporte, Cédric ; Berger, Gilles ; Dufour, Damien ; Zouaoui Boudjeltia, Karim ; Neve, Jean ; Dufrasne, François ; Van Antwerpen, Pierre
Informations sur la publication : European journal of medicinal chemistry, 123, (page 746-762)
Statut de publication : Publié, 2016-07
Sujet CREF : Chimie organique
Chimie pharmaceutique
Mots-clés : Bis-arylalkylamines derivatives
Docking
Myeloperoxidase selective inhibitors
Pharmacomodulation
Reversible inhibitors
SERT
Mots-clés MeSH : Amines -- chemical synthesis -- chemistry -- metabolism -- pharmacology
Chemistry Techniques, Synthetic
Drug Design
Enzyme Inhibitors -- chemical synthesis -- chemistry -- metabolism -- pharmacology
Halogenation
Humans
Kinetics
Molecular Docking Simulation
Oxidation-Reduction
Peroxidase -- antagonists & inhibitors -- chemistry -- metabolism
Protein Conformation
Serotonin Uptake Inhibitors -- chemical synthesis -- chemistry -- metabolism -- pharmacology
Structure-Activity Relationship
Note : SCOPUS: ar.j
Langue :
  • Anglais
Identificateurs : urn:issn:0223-5234 
info:doi/10.1016/j.ejmech.2016.07.053
info:pii/S0223-5234(16)30616-X
info:pmid/27537923
info:ulb-repo/set/1#29271