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Effects of Estrogen Receptor and Human Epidermal Growth Factor Receptor-2 Levels on the Efficacy of Trastuzumab: A Secondary Analysis of the HERA Trial.

par Loi, Sherene ;Dafni, Urania;Karlis, Dimitris;Polydoropoulou, Varvara;Young, Brandon M;Willis, Scooter;Long, Bradley;de Azambuja, Evandro ;Sotiriou, Christos ;Viale, Giuseppe;Rüschoff, Josef;Piccart-Gebhart, Martine ;Dowsett, Mitch;Michiels, Stefan ;Leyland-Jones, Brian
Référence JAMA oncology
Publication Publié, 2016-04

Article révisé par les pairs

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Résumé :

A number of studies suggest that response to antihuman epidermal growth factor receptor-2 (currently known as ERBB2, butreferred to asHER2 in this study) agents differs by estrogen receptor (ER) level status. The clinical relevance of this is unknown.