par Sergueev, Serguei ;Hesse, Manfred
Référence Helvetica chimica acta, 85, 1, page (161-167)
Publication Publié, 2002
Article révisé par les pairs
Résumé : A novel, short, and highly stereoselective synthesis of the macrocyclic spermidine alkaloid (+)-(S)-dihydroperiphylline (15) is described. The key synthetic steps were the stereoselective addition of the chiral amine 1 to the cinnamate 2 and cyclization of the bis[toluene-4-sulfonamide] precursor 12 in the presence of Cs2CO3 as a template. Unambiguous assignments of the signals in both the 1H- and 13C-NMR spectra of 15 were achieved by 2D NMR spectra.