par Panayides, Jenny Lee;Pelly, Stephen C;Kiss, Robert 
;Kornienko, Alexander;van Otterlo, Willem A L;Mathieu, Véronique ;Banuls, Laetitia Moreno Y;Apostolellis, Helen;Dahan-Farkas, Nurit;Davids, Hajierah;Harmse, Leonie;Reynaert, Christine;Green, Ivan Robert
Référence Bioorganic & medicinal chemistry, 24, 12, page (2716-2724)
Publication Publié, 2016-06
;Kornienko, Alexander;van Otterlo, Willem A L;Mathieu, Véronique ;Banuls, Laetitia Moreno Y;Apostolellis, Helen;Dahan-Farkas, Nurit;Davids, Hajierah;Harmse, Leonie;Reynaert, Christine;Green, Ivan RobertRéférence Bioorganic & medicinal chemistry, 24, 12, page (2716-2724)
Publication Publié, 2016-06
Article révisé par les pairs
| Résumé : | Seventeen silyl- and trityl-modified (5′-O- and 3′,5′-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentration of 100 μM against a small panel of tumor cell lines (HL-60, K-562, Jurkat, Caco-2 and HT-29). The entire set was also tested at varying concentrations against two human glioma lines (U373 and Hs683) to obtain GI50 values, with the best results being values of ∼25 μM. |
