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Different patterns of exhaled nitric oxide response to β2-agonists in asthmatic patients according to the site of bronchodilation

par Michils, Alain ;Malinovschi, Andrei;Haccuria, Amaryllis ;Michiels, Stefan ;Van Muylem, Alain
Référence Journal of allergy and clinical immunology, 137, 3, page (806-812)
Publication Publié, 2016-03

Article révisé par les pairs

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Résumé :

Background In asthmatic patients undergoing airway challenge, fraction of exhaled nitric oxide (Feno) levels decrease after bronchoconstriction. In contrast, model simulations have predicted both decreased and increased Feno levels after bronchodilation, depending on the site of airway obstruction relief. Objective We sought to investigate whether β2-agonists might induce divergent effects on Feno values in asthmatic patients as a result of airway obstruction relief occurring at different lung depths. Methods Feno, FEV1, and the slope of phase III of the single-breath washout test (S) of He (SHe) and sulfur hexafluoride (SSF6) were measured in 68 asthmatic patients before and after salbutamol inhalation. SHe and SSF6 decreases reflected preacinar and intra-acinar obstruction relief, respectively. Changes (Δ) were expressed as a percentage from the baseline. Results No Feno change (