par Malaisse, Willy 
Editeur scientifique Telo, Mario
Référence Reference module in biomedical research, Elsevier
Publication Publié, 2014-12
Editeur scientifique Telo, Mario
Référence Reference module in biomedical research, Elsevier
Publication Publié, 2014-12
Partie d'ouvrage collectif
| Résumé : | This article aims at reviewing briefly the current knowledge on insulin secretion with an emphasis on the following themes: the regulation of insulin release under physiological conditions; the process by which insulin secretagogues, especially D-glucose, are recognized by the islet B cells as insulinotropic agents; the mechanism of coupling between the recognition of secretagogues and more distal steps in the secretory sequence; the participation of a mechanical effector system in the exocytosis of secretory granules; the perturbation of insulin secretion in certain pathological conditions; and the pharmacological tools used to modify insulin secretion in situations of hypo- or hyperinsulinemia. |
