par Demmer, Charles 
;Evano, Gwilherm
Référence Synlett, 27, page (1873-1877)
Publication Publié, 2016
;Evano, Gwilherm Référence Synlett, 27, page (1873-1877)
Publication Publié, 2016
Article révisé par les pairs
| Résumé : | A convenient entry to yne-amides, useful building blocks for chemical synthesis whose synthesis can be rather difficult – especially in the acyclic series – is reported. They were found to be readily obtained by a simple ring opening of the corresponding, readily available yne-oxazolidinones with organolithium reagents. Surprisingly, no competitive carbolithiation of the highly reactive nitrogen-substituted alkyne or propargylic lithiation were observed, this method therefore providing a useful entry to yne-amides which can be obtained in fair to good yields. |
