par Demmer, Charles 
;Benoit, Emeline;Evano, Gwilherm
Référence Organic letters, 18, page (1438-1441)
Publication Publié, 2016
;Benoit, Emeline;Evano, Gwilherm Référence Organic letters, 18, page (1438-1441)
Publication Publié, 2016
Article révisé par les pairs
| Résumé : | An efficient and general synthesis of allenamides derived from oxazolidinones and hydantoins is reported. Upon activation with a combination of a copper catalyst and a 2,2′-bipyridine derivative in the presence of an inorganic base, propargylic bromides were found to be suitable reagents for the direct allenylation of nitrogen nucleophiles by a formal copper-catalyzed SN2′ reaction. Besides the availability of the starting materials, notable features of this route to allenamides are its mild reaction conditions, the reaction being performed at room temperature in most cases, and its applicability to the preparation of mono-, di-, as well as trisubstituted allenamides. |
