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Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

par Gillet, Nicolas;Florins, Arnaud;Boxus, Mathieu;Burteau, Catherine;Nigro, Annamaria;Vandermeers, Fabian;Balon, Hervé;Bouzar, Amel Baya;Defoiche, Julien;Burny, Arsène ;Reichert, Michal;Kettmann, Richard ;Willems, Lucas
Référence Retrovirology, 4, 18
Publication Publié, 2007

Article révisé par les pairs

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Résumé :

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far. © 2007 Gillet et al; licensee BioMed Central Ltd.