par Lecomte, Morgan ;Evano, Gwilherm
Référence Angewandte Chemie International Edition in English, 55, 14, page (4547-4551)
Publication Publié, 2016
Article révisé par les pairs
Résumé : An efficient, modular and straightforwardentry to tetrahydropyridines and piperidines is reported. This reaction is based on a formal intramolecular hydroalkylation of readily available, properly substituted ynamides which, upon simple activation under acidic conditions, generate highly reactive activated keteniminium ions whose reactivity can be finely controlled to induce aremarkably efficient [1,5]-hydride shift from unactivated C-H bonds and trigger a cationic cyclization which is complete within minutes.