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Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.

par Hall, Jason A.;Cannons, Jennifer JL;Grainger, John R;Dos Santos, Liliane M;Hand, Timothy W;Naik, Shruti;Wohlfert, Elizabeth A;Chou, David B;Oldenhove, Guillaume ;Robinson, Melody;Grigg, Michael ME;Kastenmayer, Robin;Schwartzberg, Pamela PL;Belkaid, Yasmine
Référence Immunity, 34, 3, page (435-447)
Publication Publié, 2011-03

Article révisé par les pairs

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Résumé :

Vitamin A and its metabolite, retinoic acid (RA) are implicated in the regulation of immune homeostasis via the peripheral induction of regulatory T cells. Here we showed RA was also required to elicit proinflammatory CD4(+) helper T cell responses to infection and mucosal vaccination. Retinoic acid receptor alpha (RARα) was the critical mediator of these effects. Antagonism of RAR signaling and deficiency in RARα (Rara(-/-)) resulted in a cell-autonomous CD4(+) T cell activation defect, which impaired intermediate signaling events, including calcium mobilization. Altogether, these findings reveal a fundamental role for the RA-RARα axis in the development of both regulatory and inflammatory arms of adaptive immunity and establish nutritional status as a broad regulator of adaptive T cell responses.