Titre:
  • Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.
Auteur:Andrade Da Cunha, Daniel; Ladrière, Laurence; Ortis, Fernanda; Igoillo Esteve, Mariana; Gurzov, Esteban Nicolas; Lupi, Roberto; Marchetti, Piero; Eizirik, Decio; Cnop, Miriam
Informations sur la publication:Diabetes, 58, 12, page (2851-2862)
Statut de publication:Publié, 2009-12
Sujet CREF:Enseignement des sciences
Biologie
Biologie moléculaire
Biologie cellulaire
Biologie générale
Diabétologie
Sciences bio-médicales et agricoles
MeSH keywords:Animals
Antigens, Differentiation -- metabolism
Apoptosis
Blotting, Western
Cell Survival
Colforsin -- pharmacology
DNA-Binding Proteins -- metabolism
Diabetes Mellitus, Type 2 -- metabolism -- prevention & control
Endoplasmic Reticulum -- metabolism
Glucagon-Like Peptide 1 -- agonists -- metabolism
Heat-Shock Proteins -- genetics -- metabolism
Hypoglycemic Agents -- pharmacology
Insulin-Secreting Cells -- metabolism
Lipid Metabolism -- drug effects
Male
Peptides -- pharmacology
Polymerase Chain Reaction
Proto-Oncogene Proteins -- metabolism
Proto-Oncogene Proteins c-jun -- genetics -- metabolism
RNA Interference
Rats
Rats, Wistar
Receptors, Glucagon -- metabolism
Transcription Factors -- metabolism
Up-Regulation
Venoms -- pharmacology
Langue:Anglais
Identificateurs:urn:issn:0012-1797
info:doi/10.2337/db09-0685
info:pii/db09-0685
info:pmid/19720788
PMC2780890