Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Goovaerts, Odin; Jennes, Wim; Massinga-Loembé, Marguerite; Ondoa, Pascale; Ceulemans, Ann; Vereecken, Christian; Worodria, William; Mayanja-Kizza, Harriet; Colebunders, R; Kestens, L.; Mascart, Françoise; TB-IRIS Study Group, TBSG

doi:doi/10.1371/journal.pone.0133924

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Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

par Goovaerts, Odin ;Jennes, Wim ;Massinga-Loembé, Marguerite ;Ondoa, Pascale ;Ceulemans, Ann ;Vereecken, Christian

;Worodria, William ;Mayanja-Kizza, Harriet ;Colebunders, R ;Kestens, L.;Mascart, Françoise

;TB-IRIS Study Group, TBSG; [et al.]
Référence PloS one, 10, 7, page (e0133924)
Publication Publié, 2015

Article révisé par les pairs

Résumé :

Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory complication in HIV-TB co-infected patients receiving antiretroviral therapy (ART). The role of disturbed T cell reconstitution in TB-IRIS is not well understood. We investigated T cell activation and maturation profiles in patients who developed TB-IRIS at different intervals during ART.

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