par Derks, Christian 
;Ectors, Paul ;Hoeffelman, F.
Référence Clinical Respiratory Physiology, 15, 3, page (441-454)
Publication Publié, 1979
;Ectors, Paul ;Hoeffelman, F.Référence Clinical Respiratory Physiology, 15, 3, page (441-454)
Publication Publié, 1979
Article révisé par les pairs
| Résumé : | The role of neural and humoral factors in the control of spontaneous ventilation under extracorporeal circulation was studied in 18 anaesthetized dogs. During high flow veno-arterial bypass (90±10 ml/min/kg) a prolonged apnoea or marked hypoventilation was produced whenever the carotid PO2 was above 75±10 mmHg. Hypercapnia did not exert any significant influence on ventilation. In a medium flow (60±18 ml/min/kg), hypoventilation appeared when the carotid PO2 and PCO2 were in the normal range. When the carotid PO2 was below or when the carotid PCO2 was above normal range, the animals hyperventilated. Thus under all circumstances, hypoxaemia appeared to maintain its determinant role in the control of respiration. However hypercapnia did not play a significant role during high flow veno-arterial bypass. The bilateral sections of cranial nerves IX, X and XI did not modify the phenomena described above, suggesting that the known peripheral baroreceptors and chemoreceptors are not responsible for changes in ventilatory patterns under extracorporeal circulation. |
