par Demanet, Jean Claude 
;Bonnyns, Marc ;Bleiberg, Harry ;Stevens-Rocmans, C.
Référence Lancet, 298, 7734, page (1115-1117)
Publication Publié, 1971-11
;Bonnyns, Marc ;Bleiberg, Harry ;Stevens-Rocmans, C.Référence Lancet, 298, 7734, page (1115-1117)
Publication Publié, 1971-11
Article révisé par les pairs
| Résumé : | Twelve cases of neurological syndrome due to severe hyponatræmia were investigated. Serum-sodium levels ranged between 120 and 98 meq. per litre. Neurological signs included disorders of consciousness (stage I and II coma) sometimes associated with pyramidal signs or epileptic attacks. In all cases where the electroencephalogram was recorded, it showed diffuse theta and delta waves. Hypokalæmia was frequent. In no case were there signs of intracranial hypertension. Necropsy in three cases, after correction of hyponatræmia, showed no lesions of cerebral œdema, but there were lesions characteristic of alcoholic encephalopathy in two cases. In all twelve cases, a sodium-depletion factor lay at the origin of the hyponatræmia, often associated with a dilution factor. In the seven most severe cases of hyponatræmia there was beer potomania. The importance of this factor in the pathogenesis of hyponatræmia may be explained by sodium deficiency in the diet, the absorption of large quantities of water, and the possible role of inappropriate secretion of antidiuretic hormone in these alcoholic patients. Under adequate treatment the neurological symptoms disappeared in all cases. © 1971. |
