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International collaborative study on standardization of bacterial sensitivity to fosfomycin

par Andrews, Jenny J.M.;Olay, T.;Rodriguez, Adolfo;Vicente, M. V.;Wise, Richard;Yourassowsky, Eugène ;Baquero, Fernando;Beltran, Jesús Martínez;Canton, Emilia Michael E.;Crokaert, Françoise ;Gobernado, Miguel;Gomez-lus, Rafael;Loza, Elena;Navarro, Marisa
Référence Journal of antimicrobial chemotherapy, 12, 4, page (357-361)
Publication Publié, 1983-10

Article révisé par les pairs

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Résumé :

An international collaborative study was undertaken involving 6 working groups to correlate the zone sizes obtained with 50 μg fosfomycin+25 μg glucose-6-phosphate (G6P) and 50 μg fosfomycin + 50 μg G6P/disc with the MICs in the presence of 25 mg G6P/litre. The recommendations of the ICS for the MIC and disc diffusion methods were followed and Oxoid Mueller-Hinton agar was used. The regression lines obtained with the method of least squares show that the best correlation coefficient (r= -0.8227) corresponds to the disc with 50 μg fosfomycin + 50 μg G6P. Considering both the pharmacokinetics of fosfomycin after intravenous administration of 2 or 4 g and the distribution of sensitive bacterial populations, two breakpoints were established at MIC values of 16 and 64 mg/1 corresponding to zone sizes of 18 and 12 mm, respectively. © 1983 The British Society for Antimicrobial Chemotherapy.