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Specific effect of age on lectin-induced mitogenesis of lymphocytes from diseased patients

par Brohée, Dany ;De Maertelaer, Viviane ;Piro, Pietrina;Kennes, Bernard ;Neve, Pierre
Référence Gerontology, 32, 2, page (74-80)
Publication Publié, 1986

Article révisé par les pairs

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Résumé :

Using several models of multivariate analysis, it is found that age per se is a specific determinant on the in vitro lymphocyte response to phytohemagglutinin A in a random sample of 30 diseased patients. Depending upon the used model, sex and lymphocyte subsets appear as other significant variables. The multiple regression coefficients reach 0.85. A 2% fall per decade is expected for phytohemagglutinin A responsiveness expressed in ln cpm. © 1986 S. Karger AG, Basel.