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Intrapulmonary instillation of perflurooctylbromide improves lung growth, alveolarization, and lung mechanics in a fetal rabbit model of diaphragmatic hernia

par Herber-Jonat, Susanne;Vuckovic, Aline ;Mittal, Rashmi;Hilgendorff, Anne;Jani, Jacques ;Flemmer, Andreas A.W.
Référence Pediatric critical care medicine, 15, 9, page (e379-e388)
Publication Publié, 2014-11

Article révisé par les pairs

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Résumé :

Objectives: Fetal tracheal occlusion of hypoplastic rabbit lungs results in lung growth and alveolarization although the surfactant protein messenger RNA expression is decreased and the transforming growth factor-β pathway induced. The prenatal filling of healthy rabbit lungs with perfluorooctylbromide augments lung growth without suppression of surfactant protein synthesis. We hypothesizes that Intratracheal perfluorooctylbromide instillation improves lung growth, mechanics, and extracellular matrix synthesis in a fetal rabbit model of lung hypoplasia induced by diaphragmatic hernia.