par Ring, Sabine;Mahnke, Karsten;Pushkarevskaya, Anna;Schild, Hansjörg;Probst, Hans Christian;Jendrossek, Verena;Wirsdörfer, Florian;Ledent, Catherine ;Robson, Simon Christopher Hristopher S.C.;Enk, Alexander Herrmann
Référence The Journal of immunology, 194, 8, page (3735-3744)
Publication Publié, 2015-04
Référence The Journal of immunology, 194, 8, page (3735-3744)
Publication Publié, 2015-04
Article révisé par les pairs
Résumé : | Dendritic cells (DC) are one target for immune suppression by regulatory T cells (Treg), because their interaction results in reduced T cell stimulatory capacity and secretion of inhibitory cytokines in DC.We show that DC in the presence of Treg are more mobile as compared with cocultures with conventional CD4+ T cells and form DC-Treg aggregates within 2 h of culture. The migration of DC was specifically directed toward Treg, as Treg, but not CD4+ T cells, attracted DC in Boyden chambers. Treg deficient for the ectonucleotidase CD39 were unable to attract DC. Likewise, addition of antagonists for A |