par Carpentier, Yvon ;Sobotka, Luboš
Référence e - S P E N, 3, 5, page (e188-e191)
Publication Publié, 2008-10
Article révisé par les pairs
Résumé : Lipids are not only very important energy substrates but some fatty acids and lipid-soluble vitamins act as metabolic regulators. After ingestion of a mixed meal, fat is preferentially stored in adipose tissue whereas carbohydrates are oxidized. During fasting, fatty acids are released from adipose tissue and utilized as energy substrate in liver and extra hepatic tissue. This process is effectively controlled by catecholamines and insulin, which regulate hormone sensitive lipase and lipoprotein lipase. During a critical illness, increased adipose tissue lipolysis together with decreased fatty acid oxidation leads to increased triglyceride production and deposition in the liver (and in other tissues), with an augmented production of VLDL. This situation may contribute to the aggravation of organ dysfunction. In addition, several major changes are observed with respect to the concentration and composition of plasma cholesterol-rich lipoproteins. © 2008 European Society for Clinical Nutrition and Metabolism.