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Virulent mutants of temperate phage Mu-1

par Van Vliet, Françoise ;Couturier, Martine ;Desmet, Lucie;Faelen, Michel ;Toussaint, Ariane
Référence Molecular & general genetics : MGG, 160, 2, page (195-202)
Publication Publié, 1978-01

Article révisé par les pairs

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Résumé :

Virulent mutants of phage Mu have been isolated after mutagenesis. The virulent phenotype results from most probably 2 mutations located in the c-A region of the Mu genome. Vir mutants are trans-dominant; they induce the resident prophage upon infection in broth of any Mu lysogen. They however form plaques only on certain lysogens, that are monolysogenic for a mutant prophage. We further isolated secondary mutations in Mu Vir which suppress the virulent phenotype. © 1978 Springer-Verlag.