par Bleiberg, Harry 
Référence Acta gastro-enterologica Belgica (Ed. multilingue), 37, 10-11, page (475-487)
Publication Publié, 1974
Référence Acta gastro-enterologica Belgica (Ed. multilingue), 37, 10-11, page (475-487)
Publication Publié, 1974
Article révisé par les pairs
| Résumé : | By a method of double labelling in vitro, it is easy to measure the parameters of cellular cinetics in man. Measures have been elaborated in normal digestive mucosas and in some pathologic conditions characterized by an atrophy of the mucosa. While the normal rectal mucosa is renewed every 90 hr, this renewal is performed in 34.2 hr in cases of rectocolitis. The small bowel mucosa is renewed every 31.8 hr, an atrophic small bowel mucosa every 27.9 hr. Similarly, the normal gastric mucosa is renewed after 57.8 hr, while this process takes 21.8 hr in pernicious anemia (Addison's disease). This increased proliferation speed might be, if not the very source, at least a condition fostering malignant degeneration. The labelling index in rectal polyps is generally higher than in the normal healthy neighbouring mucosa. Perhaps this may correspond to an accelerated renewal rate in a tissue in which cancer appears more frequently than in a healthy mucosa. |
