par Fontaine, Jeanine ;Reuse, Joannes
Référence Archives internationales de pharmacodynamie et de thérapie, 204, 1, page (191-195)
Publication Publié, 1973
Article révisé par les pairs
Résumé : Metoclopramide (Mcp) and procaine (Pc), added to the isolated rat stomach strip according to Vane, produce a dose related and reproducible contraction. High concentrations of Mcp (≥ 10-3 M), but not Pc, induce a relaxation of the preparation. Pharmacological analysis of these responses, using various antagonists, led to the conclusion that they are mainly of the direct musculotropic type. Indomethacin and a Ca++ free medium are able to inhibit or abolish contractions in response to both agents. On the other hand, Mcp and Pc interfere with concentration action curves to Ach and 5HT. While Pc is a weak antagonist, Mcp is able to sensitize the preparation to Ac and to antagonize 5HT responses. The results show that apart from certain similarities in the action of Mcp and Pc there are clearcut differences, which are discussed.