par Stanescu, Dinu 
;Veriter, Claude;Frans, Albert
Référence Scandinavian Journal of Respiratory Diseases, 58, 6, page (289-303)
Publication Publié, 1977
;Veriter, Claude;Frans, AlbertRéférence Scandinavian Journal of Respiratory Diseases, 58, 6, page (289-303)
Publication Publié, 1977
Article révisé par les pairs
| Résumé : | The authors studied 18 workers exposed (E) above permissible levels to cadmium (Cd) dust and fumes for an average of 32 yr in a Cd-producing factory, and 20 non-exposed control workers (C). The 2 groups were comparable with regard to age, height, weight and number of smokers and non-smokers. The excretion rate of Cd in the urine (E: 1.8 ± 0.9; C: 0.15 ± 0.06 μg/hr) and the concentration of Cd in the blood (E: 2.5 ± 1.3; C: 0.4 ± 0.2 μg/100 ml) were greater in the E than in the C group (P < 0.001). The excretion of urinary proteins was also significantly higher in the Cd group (E: 531 ± 554; C: 141 ± 85 mg/l). The proportion of workers with grade 1 dyspnea, but no other respiratory symptoms, was significantly higher among exposed workers. Independent assessment of posteroanterior and lateral chest roentgenograms and full lung tomograms failed to distinguish between the 2 groups. Closing capacity was significantly higher in the Cd-exposed group. Lung volumes, specific airway conductance (SGaw), maximal expiratory flow rates (MEFR), slope of the N2 alveolar plateau, closing volume (CV), elastic recoil of the lungs and single-breath lung diffusing capacity showed no significant difference between the 2 groups. However, in both groups, average values of SGaw, CV and MEF were outside normal limits, probably secondary to smoking (indeed, 33 out of 38 workers were smokers or ex-smokers). These results do not support the concept of Cd- induced emphysema. |
