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The effect of two low-dose contraceptives containing ethinylestradiol and desogestrel or d-norgestrel on blood clotting factors

par Vekemans, Marcel ;Grippa, Jacqueline ;Capel, Paul ;Fondu, Pierre
Référence Current therapeutic research, 42, 6, page (1109-1118)
Publication Publié, 1987

Article révisé par les pairs

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Résumé :

Twenty young women volunteered for a prospective study of the short-term hemostatic effects of two low-dose oral contraceptives. The first regimen studied in ten women was a combination of 30-μg ethinylestradiol (EE) with 150-μg desogestrel and the second regimen studied in the other ten women was a triphasic preparation of EE with d-norgestrel (d-N) (6 days 30-μg EE with 50-μg d-N; 5 days 40-μg EE with 75-μg d-N; 10 days 30-μg EE with 125-μg d-N). Blood was taken in the late luteal phase during a control cycle, and then after 3, 6, and 9 months of treatment. Each woman was her own control. The following clotting or lytic factors were determined in plasma: factors II, V, VII, VII + X, VIII (VIII-R Ag, VIII C, and VIII RCF), prothrombin time, activated partial thromboplastin time, antithrombin III, alpha2 antiplasmin, plasminogen, and fibrinogen. The data show some irregular changes in mean values of clotting factors, with no systematic trend except for plasminogen, which was significantly higher during treatment with both preparations. There was no clear-cut difference between the influence of the two contraceptives investigated.