par Danis, André 
Référence Acta orthopaedica Belgica (Ed. bilingue), 39, 4, page (696-709)
Publication Publié, 1973
Référence Acta orthopaedica Belgica (Ed. bilingue), 39, 4, page (696-709)
Publication Publié, 1973
Article révisé par les pairs
| Résumé : | The ability of bone marrow to produce bone is still an ill established conception. By animal experimentation one can demonstrate, that in aseptic conditions, the grafted marrow will turn to bone. Autologous grafts survive indefinitely, whereas homografts between animals of the same species, always are rejected. This proves that new formed bone is alien to the host and can not be produced by metaplasia of the connective tissue in the receptor area. The ossification of a piece of bone marrow in a diffusion chamber is particularly demonstrative because the interference of surrounding tissues is eliminated. A second feature, essential for the comprehension of osteogenesis in fracture callus, is the presence in the blood of medullary cells able to invade the destroyed hemopoietic tissues. The proofs are recent but unequivocal. This explains the ubiquity of ectopic ossifications, the constant finding of bone marrow in the ectopic human ossifications and also in the experimental ones; and the identical evolution of ectopic bone and medullary bone graft. The bone callus is produced directly by the bone marrow escaping through the bone leak into the neighboring tissues and indirectly by a secondary flow of cells brought by the blood stream. The cells of the bone marrow, coming from the peripheral hemopoietic tissues, converge towards the inflammatory focus of the fracture. The fate of the migrating cells depends on their meeting an adequate inductor. Thus aberrant calluses are produced, remote from bone, with tortuous shape whose formation is not at all explained by mechanical stresses. |
