par Druart, Marie-Louise 
;Hestermans, Yves ;Woussen Colle, Marie-Claire ;De Graef, Jacques
Référence Gastroentérologie clinique et biologique, 5, 8-9, page (719-727)
Publication Publié, 1981
;Hestermans, Yves ;Woussen Colle, Marie-Claire ;De Graef, Jacques Référence Gastroentérologie clinique et biologique, 5, 8-9, page (719-727)
Publication Publié, 1981
Article révisé par les pairs
| Résumé : | Gastric acid output, gastric emptying and serum gastrin levels were measured in four dogs after the intra-gastric administration of water or peptone solutions. The effects of somatostatin infusions from 0.156 to 2.5 μg/kg/h were studied on these three parameters. The results confirm that somatostatin doses of approximately 2,5 μg/kg/h inhibit acid secretion and post-prandial gastrin release. They also show that this peptide inhibits gastric emptying of liquids. The lowest dose of somatostatin infused (0.156 μg/kg/h) sometimes induced reactions opposite to those obtained with higher doses: stimulation of gastric emptying of water increase in acid output and gastrin release after administration of a peptone meal. These paradoxical effects probably result from the multiple effects of somatostatin and the interactions between gastric secretory and motor functions. The fast that somatostatin acts on the stomach at doses of approximately 0.1 μ/kg/h suggests that post-prandial increase in blood somatostatin levels could alter both the secretory and motor functions of the stomach. |
